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(Minoxidil (6-piperidin-1-ylpyrimidine-2,4-diamine 3-oxide
Triethylamine-bonded sulfonic acid {[Et3N-SO3H]Cl} as an efficient and homogeneous catalyst for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones
Abstract
Brønsted acidic ionic liquid triethylamine-bonded sulfonic acid {[Et3N-SO3H]Cl} efficiently catalyzes the one-pot multi-component condensation of 2-naphthol with arylaldehydes and dimedone (5,5-dimethylcyclohexane-1,3-dione) under solvent-free conditions to afford 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones in high yields and relatively short reaction times.
Key words: Ionic liquid, xanthene, 2-Naphthol, Arylaldehyde, Dimedone
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شیمی فیزیک آلی یا "شیمیِ آلیِ فیزیکی"
organic physical chemistry or physical organic chemistry
Copyright © 2012 Elsevier B.V. All rights reserved
Discovery of an in situ carbocationic system using tritylchloride as a homogeneous organocatalyst for the solvent-free condensation of β-naphthol with aldehydes and amides/thioamides/alkyl carbamates in neutral media
Trityl chloride (TrCl), efficiently catalyzes the one-pot multi-component condensation of β-naphthol with aromatic aldehydes and amides/thioamides/carbamates such as acetamide, benzamide, nicotinamide, thioacetamide, and methylcarbamate under solvent-free and neutral conditions to afford 1-amido-alkyl-2-naphthols, 1-thioamido-alkyl-2-naphthols, and 1-carbamato-alkyl-2-naphthols in high yields and very short reaction times. Mechanistically, it is interesting that trityl chloride through the in situ generation of trityl carbocation with inherent instability is efficient as a reusable homogeneous organocatalyst in neutral media
Keywords: Trityl chloride - Multi component condensation - Solvent free
نوشیدن آب گریپ فروت می تواند بر روی بعضی داروها تاثیرگذار باشد. بدین ترتیب که در اغلب موارد، سطح دارو را در خون افزایش می دهد. این امر می تواند ریسک عوارض جانبی را بالا برده و یا به طور کل، اثر دارو را تغییر دهد. گریپ فروت همچنین ‘فعالیتهای آنزیمی’ که بدن برای پردازش بیش از ۵۰ دارو به آن نیاز دارد را کاهش می دهد.
Copyright © 2012 American Chemical Society
Design of Ionic Liquid 3-Methyl-1-sulfonic Acid Imidazolium Nitrate as Reagent for the Nitration of Aromatic Compounds by in Situ Generation of NO2 in Acidic Media
Abstract
3-Methyl-1-sulfonic acid imidazolium nitrate ([Msim]NO3) as a new Brønsted acidic ionic liquid and nitrating agent was prepared and used for the efficient nitration of aromatic compounds (even aniline derivatives). The dramatic effect of this reagent by in situ generation of nitrogen dioxide as a radical on aromatic compounds to give nitroarenes has been studied
Copyright © Georg Thieme Verlag Stuttgart · New York
In this work, at first, triazenes were synthesized from primary aryl amines. Afterwards, triazenes were converted into the corresponding thiophenols in one-pot using sodium sulfide in acidic media, by in situ generation of diazonium counterion beside hydrogen sulfide as anionic sulfur nucleophile at room temperature. The procedure can be a convenient shortcut for the preparation of thiophenols from primary aryl amines
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